We seek to use diverse technologies like genomics, synthetic biology, and genome engineering to target and manipulate the microbiota for therapeutic purposes. We primarily use the human skin microbiome as a system to understand the complex interactions between the host, its immune system, and the microbiome. Some of our research goals are to:
1. Integrate synthetic approaches guided by microbial surveys to develop clinical interventions that target pathogens without disrupting our bodies’ healthy microbiota.
2. Use these tools to understand the genetic basis of community homeostasis and how this interaction with the host contributes to disease.
3. Develop computational and experimental tools to interrogate microbial 'dark matter', parts of our microbiota that are not yet characterized by current approaches.